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The Potential to Forever Change How Cancer is Treated

Allogene Therapeutics is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR TTM) therapies for cancer. The goal of our allogeneic cell therapy platform is simple: take the same biological processes that allow the first generation autologous CAR T (Auto CAR TTM) therapies to deliver breakthrough clinical benefits but eliminate the need to create a personalized therapy for each patient. Instead, we start with T cells from healthy donors, which is intended to allow for creation of inventory for “off-the-shelf” use in patients faster, more reliably, and at greater scale.

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Accelerating an Expansive Portfolio

We are advancing our AlloCAR TTM portfolio acquired from Pfizer, which includes rights to 16 preclinical CAR T cell therapy targets licensed from Cellectis and Servier and U.S. rights to clinical candidates ALLO-501 and UCART19.

Allogene initiated its Phase 1 ALPHA study of ALLO-501 in 1H 2019 to assess safety and tolerability of ALLO-501 and ALLO-647, our proprietary anti-CD52 monoclonal antibody, in patients with relapsed/refractory non-Hodgkin lymphoma (NHL). Servier is the sponsor of the UCART19 program, which is currently in Phase 1 for the treatment of relapsed/refractory acute lymphoblastic leukemia (ALL).

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Led by a Veteran Team

Our world-class management team has significant experience in cell therapy. Allogene co-founders include Dr. Arie Belldegrun and Dr. David Chang, who developed one of the first CAR T cell therapies approved by the U.S. Food and Drug Administration. The team has unparalleled scientific, clinical and regulatory expertise, and a track record of success.

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